| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_555896a2f43ea629dbc0f99b94cfd297
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bdc701a10acac1579e9c203a9b7620ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_758b18878e7620a31ad005f8909e75c8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N- |
| filingDate |
2004-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f6d661a27f32b248285c8ca0fe7b961
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_face6f3af6a47164d55aac445ea0f81b |
| publicationDate |
2005-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005022118-A2 |
| titleOfInvention |
Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics |
| abstract |
The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the individual. The present invention also provides methods for generating a pharmacogenetic index for predicting clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. In addition, the present invention provides methods for optimizing therapeutic efficacy of chemotherapy in an individual by calculating the level of at least one long-chain MTXPG in a sample obtained from the individual. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3101142-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008026922-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016170331-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1877579-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9822391-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2722404-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008010085-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1776472-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1776472-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8712696-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012037068-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1877579-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008010085-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9261509-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8073630-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017000006-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7695908-B2 |
| priorityDate |
2003-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |