| abstract |
The invention concerns recombinase-mediated transfer of human or humanized immunoglobulin loci into the genome of non-human transgenic animals. In particular, the invention relates to improved methods to integrate human and/or humanized immunoglobulin loci into the genome of non-human animals using transgenic constructs which contain immunoglobulin loci comprising human gene sequences and a site recognized by a site specific recombinase which can be used to catalyze the insertion of the transgene into the animal's genome. |