| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4c6a2eb66d07fad39d708e5a36c9350 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate |
2014-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49907bc18dc28ca4c46857551942a41c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_495c41519254e13ed44ce8ae475de3bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2f3a866735a501b1cb92f49b8ca33c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7903cceec74ec596e60d5824e6cca45e |
| publicationDate |
2017-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9783618-B2 |
| titleOfInvention |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| abstract |
The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to the provision of novel V, D and J pairings in immunoglobulin heavy and light chain loci. Novel, biased antibody diversities and potentially expanded diversities are provided. The invention also provides for novel and potentially expanded diversity or diversity that is biased towards variable gene usage common to antibodies useful for treating and/or preventing certain diseases or conditions, such as infectious diseases. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11297810-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11297811-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11606941-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017099817-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11399522-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774155-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11707056-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10667501-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10226033-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017105396-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10730930-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012204278-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11051497-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11564380-B2 |
| priorityDate |
2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |