| abstract |
A nucleotide derivative is disclosed, which in its 4' and/or 5' position on the sugar moiety is substituted with a group comprising a non-aromatic cyclid group comprising at least one nitrogen atom, said cyclid group optionally being substituted. The nucleotide monomer induces increased thermal stability of RNA:DNA, RNA:RNA or DNA:DNA duplexes, if said RNA and/or DNA strand comprises at least one said monomer. The nucleotides and oligonucleotides comprising at least one of said nucleotides can be used in therapy (such as antisense or antigene therapy) and in methods for synthesising polynucleotides (e.g. as a primer). The nucleotide derivative may also be used in a medicament. Further, the use of the nucleotide derivative for the preparation of a medicament for the treatment of diseases or disorders is also disclosed. |