| abstract |
Method for preparing a target substance in particulate form, by introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a solution or suspension of the target substance in a fluid vehicle (the 'target solution/suspension') and (b) à compressed fluid anti-solvent for the substance, and allowing the anti-solvent to extract the vehicle from the target solution/suspension so as to form particles of the target substance, the anti-solvent having a sonic, near-sonic or supersonic velocity as it enters the particle formation vessel, wherein the anti-solvent and the target solution/suspension enter the vessel at différent locations and meet downstreazn (in the direction of anti-solvent flow) of the second fluid inlet, and wherein the outlet of the first fluid inlet has a diameter of less than 0.1 mm. |