| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f08160e32923414e5d3c07077503556e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f600d1296c13d2e86af0e53efe367729
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_815a41b0d76bbf1707fbbf2976c3a181
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_815f0328674c0126f8bf5565e589b06d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6811 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2003-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_012dc4de17f8b7b299da3195a105efad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f1a9a196bfebcf6256297e77bcbd501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2342299b92831072443562e4c04dbfdb |
| publicationDate |
2004-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004050885-A2 |
| titleOfInvention |
Control of apoptosis using a complex of an oligonucleotide and a regulatory peptide |
| abstract |
A method for suppressing the expression of a selected apoptosis-related gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site at or associated with the selected gene which site is present in a genome and (2) a modifying portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor or modifying portion may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase. The nucleic acid binding portion may be a triplex forming oligonucleotide (TFO). The apoptosis-related gene may be Bcl-2. The methods and molecules may be useful in the treatment of cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10087420-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8815599-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10442853-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10786534-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10556006-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8367628-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7807647-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008517903-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9789135-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9775897-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9428571-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11369678-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10864259-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7524827-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7498315-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-1027311-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116796-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10272115-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11667695-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9393258-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10953048-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006043810-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10206952-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10760055-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102004043155-A1 |
| priorityDate |
2002-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |