| abstract |
Cyanopyrrolidine derivatives represented by the general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein W is an acyl group derived from a natural amino acid, a group represented by the general formula (2): (2) (wherein W1 is C1-5 alkanoyl, optionally substituted arylcarbonyl, or C1-5 alkyl; and W2 is hydrogen or C1-5 alkyl), or a group represented by the general formula (3): (3) (wherein W3 and W4 are each hydrogen or C1-5 alkyl); X is oxygen or sulfur; Y is -CR5R6- (wherein R5 and R6 are each independently hydrogen, halogeno, or the like) or -CR7R8-CR9R10- (wherein R7, R8, R9, and R10 are each independently hydrogen, halogeno, or the like); and Z is hydrogen or optionally substituted C1-10 alkyl, or Y and Z together with the nitrogen atom adjacent to them may form an optionally substituted cyclic amino group having 2 to 10 carbon atoms. |