| abstract |
(57) N- (N'-substituted glycyl) -2-cyanopyrrolidine, for example of the formula I: The compounds of the formula wherein R has various meanings are novel. They inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore medicaments for the inhibition of DPP-IV and the treatment of diseases mediated by DPP-IV such as non-insulin-dependent diabetes, arthritis, obesity and osteoporosis and further conditions of reduced glucose tolerance. Is indicated. |