| abstract |
Compounds of formula (II) have antibacterial activity: wherein Q represents a radical of formula -N(OH)CH(=0) or formula -C(=O)NH(OH); R1 represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula -N(OH)CH(=0), a hydroxy, halo or amino group; R2 represents a group R10-(V)n-(ALK)m- wherein R10 represents hydrogen, or an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C1-C6 alkylene, C2 -C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent -NH-, -O- or -S- linkages, V represents -NH-, -O- or-S-, m and n are independently 0 or 1; R3 represents the side chain of a natural or non-natural alpha amino acid; R4 represents hydrogen or C1-C3 alkyl; Y represents N or CH; ring A is optionally substituted on one or more ring carbon atoms by C1-C3 alkyl, C1-C3 alkoxy, or halo; and R5 represents a group (IIA): wherein m is 0 or 1; Alk1 represents a divalent C1-C3 alkylene radical; Z represents hydrogen or an optionally substituted cycloalkyl, phenyl or heterocyclic group. |