| abstract |
(57) [Summary] [Object] An object of the present invention is to provide a novel and useful compound having a pharmacological activity such as a collagenase inhibitory activity and a pharmaceutically acceptable salt thereof. [Structure] Expression [Wherein R 1 is hydrogen or a hydroxy protecting group, R 2 is hydrogen, a lower alkyl group or an amino protecting group, R 3 is hydrogen or a 2-thienylthio group, R 4 is a 2-pyridyl group or its N-oxide, 4-pyridyl group. , A phenyl group or a 4-methoxyphenyl group, and R 5 represents a hydroxy group, a lower alkoxy group or an amino group having a substituent, respectively. However, when R 1 and R 2 are each hydrogen, R 4 is a 2-pyridyl group or its N-oxide or 4-pyridyl group. ] The compound represented by these, or those salt accept | permitted pharmaceutically. |