| abstract |
The invention relates to a new gene 098P4B6 (also known as STEAP-2) and its encoded protein, and variants thereof. 98P4B6 has specific tissue expression in nominal adult tissue, and is expressed aberrantly in the cancers listed in Table 1. 98P4B6 thus constitutes a diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. The 98P4B6 gene or a fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to obtain a humoral or cellular immune response. The invention also relates to antibodies or T cells reactive to 98P4B6, which can be used in active or passive immunization. |