| abstract |
It is intended to provide a novel N-hydroxycarboxamide derivative which is excellent in physical properties such as stability and dissolution properties and a potent histone deacetylase (HDAC) inhibitory activity. It is found out that a novel N-hydroxycarboxamide derivative, which is obtained by using tranexamic acid as a lead compound, and its salt have a potent HDAC inhibitory activity. This N-hydroxycarboxamide derivative is useful in treating, relieving and preventing diseases concerning cell proliferation. In particular, it is expected that this derivative is highly efficacious as an anticancer agent or a carcinostatic agent. Moreover, it is expected that the above N-hydroxycarboxamide derivative is efficacious as an immunosuppressant or a gene therapy potentiator and usable in treating, relieving and preventing neurodegenerative diseases. |