| abstract |
FIELD: pharmacology. n SUBSTANCE: invention relates to new compounds of formula I, their optical isomers or pharmaceutically acceptable salts that can be used for treatment of diseases mediated by histone deacetylase. In formula I, A is , Xa and Xb are CH, L 1 and L 2 independently hydrogen, -F, -Cl, -Br or -I, Q is C(=O), Y is selected from the group consisting of , and , M is C, O or N, l and m are independently 0 or 1, each of R a1 and R a2 is independently hydrogen; hydroxy; linear or branched -C 1-4 -alkyl, etc., n is 0, 1 or 2, R b is hydrogen; hydroxy; linear or branched -C 1-6 -alkyl, etc., Z is selected from the group consisting of , etc., where each of P a and P b is independently ; hydrogen; hydroxy; linear or branched -C 1-4 -alkyl, etc., where is selected from phenyl, pyridine, pyrimidine, thiazole, indole, indazole, etc., each of x, y and z is independently 0 or 1, and each of R g1 , R g2 and R g3 is selected independently from hydrogen; hydroxy; -C 1-3 -alkyl, etc. The invention also relates to a pharmaceutical composition comprising compounds of formula I, a method for treatment of diseases mediated by histone deacetylase and application of said compounds for drugs preparation. n EFFECT: increased effeciency of compound application. n 9 cl, 7 dwg, 16 tbl, 173 ex |