| abstract |
A compound represented by the formula (I) (wherein A represents -NR1-(CH2)m- (R1 is hydrogen or lower alkyl and m is an integer of 2 to 5 or a single bond); Z1 and Z2 each independently is hydrogen or a substituent selected from the group consisting of lower alkyl, lower alkoxy, lower alkenyl, halogeno, halogenated lower alkyl, halogenated lower alkoxy, hydroxy, carboxy, and nitro; and n is an integer of 1 to 3). It has an antagonistic effect on an NMDA receptor, and is hence useful as a remedy for brain infarction in the acute stage, remedy for chronic nerve degeneration diseases, analgesic, etc. |