| abstract |
Modified release pharmaceutical formulations and methods for enhanced mucosal drug absorption. The formulation comprises initial population(s) of particles comprising both drug and penetration enhancer which are released at a first location in the gastrointestinal tract, and a subsequent population or populations of particles comprising a penetration enhancer(s) having a delayed release due to a polymeric coating or matrix. This penetration enhancer is released at an additional location( s ) in the intestine downstream from the first location and enhances absorption of the drug when it reaches the additional location(s). |