| abstract |
An optically active isomer of a quinazolinone derivative represented by the general formula (1): (1) (wherein Y represents phenyl or C2-7 alkyl; E represents -CH= or nitrogen; and R represents C1-4 alkyl, etc.) or a pharmaceutically acceptable salt of the isomer. They have M3-selective muscarine receptor antagonism and function to reduce the frequency of rhythmical urinary bladder contraction. They are useful in treatments for frequent urination or urinary incontinence. |