| abstract |
The present invention provides, inter alia, a glyphosate resistant EPSPS enzyme wherein in comparison with the wild type enzyme the EPSPS protein sequence is modified in that a first position is mutated so that the residue at this position is Ile rather that Thr and a second position is mutated so that the residue at this position is Ser rather than Pro, the mutations being introduced into EPSPS sequences which comprise the conserved region GNAGTAMRPL in the wild type enzyme such that modified sequence reads GNAGIAMRSL. The invention also includes glyphosate resistant plants regenerated from material transformed with polynucleotides which encode such EPSPS enzymes and a method of selectively controlling weeds in a field comprising such plants and glyphosate sensitive weeds, by the application to the field of glyphosate or an agronomically acceptable derivative. |