| abstract |
Compounds represented by the general formula (I) and having excellent inhibitory activity against the degradation of cartilage matrix; or salts or sulfoxides of the same: (I) wherein R1 is -(S)n-R2 (wherein R2 is optionally substituted hydrocarbyl or the like; and n is an integer of 0 to 2) or the like; R5 is hydrogen, optionally substituted hydrocarbyl, or the like; symbol (II) is a group represented by the general formula (III) or the like; and symbol (IV) is a group represented by the general formula (V) or the like: (II) (III) (IV) (V) [wherein R6 is hydrogen, optionally substituted hydrocarbyl, or the like; R10 is -ZR15 (wherein Z is -SO2- or the like; and R15 is optionally substituted hydrocarbyl or the like) or the like; and R11 is hydrogen or the like]. |