| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1224e300c05e5439225bd3d75c9d23ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f137c31e20b6212272dde0619058fce3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b0c198757da18cf77dfbdcef00abb70 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 |
| filingDate |
2002-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24c7806d9108604680467fe457a56c62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a71e5a7a2be086291f6a924e3ef90f1 |
| publicationDate |
2002-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-02083639-A1 |
| titleOfInvention |
Process for nitrating photocleavable compounds |
| abstract |
A process is disclosed for nitrating photocleavable compounds comprising a photocleavable group linked to an effector moiety which are capable of releasing the effector moiety on irradiation with light or a group is capable of linkage to an effector moiety. The process employs copper (II) nitrate and acetic anhydride to nitrate substituted indolines at the 7-position. This reaction which proceeds in good yield and selectivity and can be carried out in the presence of the functional groups at the 4-position and/or the effector moiety which is typically linked via an acyl linkage to the heterocyclic nitrogen at the 1-position. These nitration conditions have the advantages of a favourable isomeric ratio of products and leaving the protecting groups intact, thereby giving additional scope for isomer separation. In a preferred embodiment, the present invention employs clay supported copper (II) nitrate ('claycop') and acetic anhydride which provides improved yield and isomeric ratio as compared to the use of homogeneous, soluble copper (II) nitrate. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004085394-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1757585-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7737169-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104011020-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102977000-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9650664-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013050798-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11370757-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013050795-A1 |
| priorityDate |
2001-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |