| abstract |
An isolated, water-soluble polypeptide derived from tryptophanyl-tRNA synthetase is useful for the inhibition of angiogenesis. The polypeptide consists essentially of the amino acid residue sequence SAKGIDYDKL IVRFGSSKID KELINRIERA TGQRPHHFLR RGIFFSHRDM NQVLDAYENK KPFYLYTGRG PSSEAMHVGH LIPFIFTKWL QDVFNVPLVI QMTDDEKYLW KDLTLDQAYG DAVENAKDII ACGFDINKTF IFSDLDYMGM SSGFYKNVVK IQKHVTFNQV KGIFGFTDSD CIGKISFPAI QAAPSFSNSF PQIFRDRTDI QCLIPCAIDQ DPYFRMTRDV APRIGYPKPA LLHSTFFPAL QGAQTKMSAS DPNSSIFLTD TAKQIKTKVN KHAFSGGRDT IEEHRQFGGN CDVDVSFMYL TFFLEDDDKL EQIRKDYTSG AMLTGELKKA LIEVLQPLIA EHQARRKEVT DEIVKEFMTP RKLSFDFQ (SEQ ID NO: 12) or an angiogenesis inhibiting fragment thereof. The isolated polypeptide has a size of no more than about 45 kilodaltons. Methods of use of the polypeptide are also provided. |