| abstract |
A process for the production of sulfonic ester derivatives of the general formula (4) or (5) by reacting an amino alcohol of the general formula (1) or (2) with an organic sulfonyl halide of the general formula (3) in a mixed solvent of an aprotic organic solvent and water in the presence of a non-water-prohibitive inorganic base. This process is reduced in the load on the environment and can be carried out simply, safely and economically: (1) (2) (3)(4) (5) wherein n is an integer of 0 to 5; A is optionally substituted phenyl; R is methanesulfonyl, ethanesulfonyl, p-toluenesulfonyl, or p-nitrobenzenesulfonyl; and X is chloro, bromo, or iodo. |