http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0135986-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d189b10028d1697dc0392efe2902921 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4229c3b23c9809bf6b6e55d46bfd9474 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41424fefe02821e242f46441416f4e71 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-044 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-202 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 |
| filingDate | 2000-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b5da74e09abcb2455fed92f05eb7e1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9e74f4e9d6c92a7e7f8d7354d1e3dcc |
| publicationDate | 2001-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0135986-A3 |
| titleOfInvention | Methods and compositions for modulating er-stress-induced cholesterol accumulation |
| abstract | The present invention provides methods for preventing the accumulation of cholesterol/triglycerides within mammalian cells. The present methods are based upon the surprising discovery that ER stress in a cell leads to cholesterol/triglyceride accumulation within the cell, which cholesterol/triglyceride accumulation is often a causative factor in the development of any of a number of conditions or diseases, such as atherosclerosis. The ER stress can be the result of any of a variety of causes, including homocysteine, viral infection, and hypoxia. Accordingly, counteracting the progression or the severity of ER stress can be used to inhibit the accumulation of cholesterol/triglycerides in said cell, thereby preventing or lessening the severity of any of a number of cholesterol-related diseases or conditions, e.g., atherosclerosis. In addition, the presence of ER stress in a cell can be used to diagnose a cholesterol associated disease, or to predict the propensity of a mammal to develop a disease. |
| priorityDate | 1999-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.