| abstract |
The polynucleotide and polypeptide sequences of two novel hypoxia-inducible human genes, HIG1 and HIG2, are described. In addition, a number of known genes and ESTs have now been established as being hypoxia-inducible and hypoxia-repressible. Polynucleotide and polypeptide arrays comprising the hypoxia-inducible and hypoxia-repressible gene sequences, proteins, or antibodies which specifically bind the proteins are disclosed. Methods for using the hypoxia-inducible and hypoxia-repressible gene sequences and proteins, and arrays thereof, to diagnose and treat hypoxia-related conditions such as cancer and ischemia are also provided. |