| abstract |
Compositions and methods for treating and/or preventing in mammals, particularly humans, acute inflammatory responses and diseases, such as viral hemorrhagic diseases or disorders, sepsis and other diseases involving such responses are provided. More particularly, compositions and combinations of compositions and methods for the treatment or prevention of disorders, especially acute inflammatory disorders involving pathological responses of the immune system, such as viral hemorrhagic diseases, sepsis, rheumatoid arthritis and other autoimmune disorders, acute cardiovascular events, flare-ups and acute phases of multiple sclerosis, wasting disorders and other disorders involving deleterious expression of cytokines and other factors, including tumor necrosis factor (TNF) and interleukin-1 (IL-1) are provided. Also provided, are cytokine receptor enriched compositions and methods of preparing the compositions. |