| abstract |
A method for treating or preventing malaria in a subject is provided. A method of treating or preventing malaria, wherein an effective amount of a substituted tetracycline compound is administered to a subject. The tetracycline compound is a compound represented by Formula I. Wherein X is CR6′R6, O, etc., R2, R2 ′, R4 ′, and R4 ″ are individually hydrogen, etc., R4 is NR4′R4 ″, etc., and R3, R11, And R12 are each hydrogen or the like, R10 is hydrogen or the like or is bonded to R9 to form a ring, R5 is hydroxyl or the like, and R6 and R6 ′ are each independently hydrogen R7 is a malaria interaction part or the like, R9 is a malaria interaction part or the like, and R13 is hydrogen or the like. [Selection figure] None |