| abstract |
The present invention relates to methods and compositions for modulating the release of cytokines by αEβ7-expressing cells. Binding polypeptides and other molecules which selectively bind to αEβ7 and, thereby, block or enhance the Th2 cytokine response by the αEβ7-expressing cell, also are provided. The antagonists and agonists of the invention are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating cytokine release by αEβ7-expressing cells. Methods and pharmaceutical compositions for modifying the Th2 cytokine response by an αEβ7-expressing cell, in vitro and in vivo also are provided. |