| abstract |
Compounds of formula (I) are described in which Het is a five or six membered heteroaromatic ring of formula (i) in which one of R?1 and R2¿ is optionally substituted heteroaryl and the other is optionally substituted heteroaryl or optionally substituted aryl; X1 is a bond, X?3 and X4¿ are each independently N or C and X?2 and X5¿ are independently CH, N, NH, O or S; or X?3 and X4¿ are C, one of X?1, X2 and X5¿ is N and the others are N or CH; but excluding compounds in which X1 is a bond, one of X?2 and X5¿ is N and the other is NH and X?3 and X4¿ are both C; R3 represents a group -L?1-R6; R4¿ represents hydrogen, alkyl or hydroxyalkyl; or R?3 and R4¿, when attached to the same carbon atom, may form with the said carbon atom a cycloalkyl, cycloalkenyl or heterocycloalkyl ring or a group C=CH¿2; R?5 represents hydrogen or alkyl; and m is zero or an integer 1 or 2; and N-oxides thereof, and their prodrugs; and pharmaceutically acceptable salts and solvates of compounds of formula (I) and N-oxides thereof, and their prodrugs. The compounds are TNF inhibitors and are useful as pharmaceuticals. |