| abstract |
Imidazole derivatives of the formula:n n wherein R¹ represents optionally substituted phenyl, R² represents alkyl optionally substituted by hydroxy, X¹ represents a bond, oxygen, -S(0) n -, -CH₂0- or - CH₂N(R⁶)-, wherein n is 0, 1 or 2 and R⁶ represents hydrogen, alkyl, acyl alkylsulphonyl or, -C(X³)NR⁷R⁸, wherein X³ represents oxygen or sulphur and R⁷ and R⁸ represent hydrogen, alkyl, or optionally substituted phenyl, m is zero or 1 to 8, X² represents a bond, oxygen, -S(0) p - wherein p is 0, 1 or 2, or a group -C(0)NR⁴-, -C(S)NR⁴-, -OC(0)NR⁴-, -OC(S)NR⁴-, -NR⁴C(0)- or -NR⁴C(S)-, wherein R⁴ represents hydrogen or alkyl and R³ represents optionally substituted heterocyclyl, or cycloalkyl or, except when X¹ and X² are direct bonds, R³ represents optionally substituted phenyl, or R³ represents amino, alkylamino, benzylamino, benzyl(alkyl)amino, dialkylamino, aminoalkyl, alkylaminoalkyl, benzylaminoalkyl, benzyl(alkyl)aminoalkyl or dialkylaminoalkyl, or a cyclic imino group, and salts thereof possess useful pharmacological properties. |