abstract |
Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2-) scavengers, β-adrenergic agonists, cAMP-dependent protein kinase activators, α¿1?-adrenergic antagonists, L-type Ca?2+¿ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used. |