| abstract |
A pharmaceutical compound of formula (I) in which R?1 and R2¿ are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, X is (1) or (2), Y is (3) or (4) where R?4 and R5¿ are each hydrogen, C¿1-6? alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl, n is 0 or 1, and R?3 is -SR6, -SOR6, -SO¿2R?6, -COR6, -CH¿2OH or -CONHR7, where R6 is C¿1-6? alkyl and R?7¿ is hydrogen or C¿1-6? alkyl; provided that when one of R?1 and R2¿ is hydrogen and the other is fluoro, X is (1), Y is (4), R?4 and R5¿ are each hydrogen or C¿1-6? alkyl, and n is 0, then R?3¿ is not -COR6 or -CONHR7; and salts thereof. |