http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE37045-E
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a4cad18cb5cd7cab60d29718192e238 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 |
| filingDate | 1999-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7f34ec3071304217362a10efa2a154b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee96e1b6c96fd7dda10798e783d7bd3e |
| publicationDate | 2001-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-RE37045-E |
| titleOfInvention | N-6 substituted-5′-(N-substituted carboxamide)adenosines as cardiac vasodilator and antihypertensive agents |
| abstract | Compounds of the formula n are disclosed, wherein R 1 , represents secondary alkyl; aralkyl; cycloalkyl; heteroaryl substituted alkyl; norbornyl; and substituted secondary alkyl, aralkyl, cycloalkyl, heteroaryl substituted alkyl, norbornyl; and para-substituted phenyl groups; and R 2 and R 3 are hydrogen or pharmacologically acceptable acyl groups. The compounds of the invention are useful as cardiovascular vasodilator or anti-hypertensive agents. The therapeutically useful compounds of the invention as well as similar 5-N and N-6 substituted adenosine 5-uronamides are prepared, in accordance with a novel process, from isopropylidene (or otherwise suitably blocked) inosine-5′-uronic acid. Isopropylideneinosine-5′-uronic acid is reacted with a suitable inorganic acid halide, such as thionyl chloride, to yield 6-halogeno-9-[2′,3′-O-isopropylidene-β-D-ribofuranosyl-5-uronic acid halide]-9H-purine. This intermediate is reacted with an amine of the general formula R 4 R 5 NH to give a 6-halogeno substituted, substituted uronic acid amide of the formula n wherein X is halogen. Reaction of the latter intermediate with an amine of the formula R 1 —NH 2 , and removal of the isopropylidene (or other) blocking groups yields the compounds of the invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6784165-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006079479-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005118262-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6995148-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004242531-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004242930-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011059915-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005009776-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8133880-B2 |
| priorityDate | 1984-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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