| abstract |
N 6 -substituted adenosines of the formula ##STR1## wherein R 1 and R 2 each are a hydrogen atom or an alkyl, aralkyl, aryl or heterocyclic ring, or R 1 is a hydrogen atom and R 2 is hydroxy, amino, alkyl terminally substituted, or R 1 and R 2 collectively with the nitrogen atom are a heterocyclic ring; R 3 is a hydrogen atom, amino or silylated amino; and Z is a phosphoric acid esterified sugar radical; possess antiproliferative activity and have beneficial effects upon the cardiovascular system; are produced by reacting a 6-trialkylsilyloxy purine of the formula ##STR2## wherein each alkyl are alike; R 3 ' is a hydrogen atom or trialkyl silylamine; and Z' is a sugar radical blocked with a phosphoric acid ester group, with ammonia or a primary or secondary amine, or with a corresonding salt of the amine, employing the amine salt or a Lewis acid as reaction catalyst. |