| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate |
2012-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4cc69e7f8f681485b40a3d5e31fce63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca65c2798f31d05628ad8b4097df3e74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_575fbb7505f49116be04d118d79f5dd5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09ba22fe11954c5e8db9dfa341bf03cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41563ac3357b849aa3c26a369cb15988 |
| publicationDate |
2016-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9493474-B2 |
| titleOfInvention |
Inhibitors of the renal outer medullary potassium channel |
| abstract |
This invention relates to compounds of Formula I having the following general structure:n nZ 1 —Y 1 —(CH 2 ) n1 —R—(CH 2 ) n2 —Y 2 —Z 2 n nwherein R represents a fused bicyclic or spirocyclic aliphatic diamine and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160751-B2 |
| priorityDate |
2011-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |