| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_06e37c216a605fbb56dbf539641cc5cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c99835f1105195b095f2288aa04cd56e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3120ae9cab5bb4831f0cc16288966367 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-625
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-625
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate |
2012-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8a5e8c3abffb77d3872ed05a9536621
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc70b4f398c6024239977bf6ca1f9ce |
| publicationDate |
2016-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9447163-B2 |
| titleOfInvention |
Purification of insulin |
| abstract |
The present application discloses a chromatographic process for separating protein components of a protein-containing solution, the solution comprising an insulin peptide and one or more di- or polyvalent metal ions, the insulin peptide being capable of self-association and/or structural change in the presence of di- or polyvalent metal ions, the process comprising the steps of: a) applying the protein-containing solution to a column of a chromatographic solid phase material, wherein the loading of the insulin peptide is at least 6.0 g per liter of column volume (g/L CV ); and b) eluting the insulin peptide from the solid phase material using an eluent having a pH of at the most 8.5; and collecting a pool of the insulin peptide corresponding to at least 75% by weight of the insulin peptide applied to the column in step (a). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10137172-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10335464-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10596229-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11167035-B2 |
| priorityDate |
2011-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |