| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd7097ef1503fdfd4f6fda94c180ade8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_54c54270254cf5d25f864e2a48ddf04d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0694 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95733488479d391bf1b62cdc5c469035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b1e76db4bec118cc95ec47d5550e789
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e94cef190d1b2e25ef7c599a9d3a8ce1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_593a06a68022c8f9dd8916767de9012f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4e26c3146339ee8a79712c3049843a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c3c6a4b77161d190625c1874f8388a1 |
| publicationDate |
2016-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9267938-B2 |
| titleOfInvention |
Ex vivo human multiple myeloma cancer niche and its use as a model for personalized treatment of multiple myeloma |
| abstract |
The described invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a microfluidic device. The dynamic MM cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow (BM) niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the BM niche, and the viability of the human myeloma cells is maintained by the MM cancer niche. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10184113-B2 |
| priorityDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |