| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77c2f907d13534169a46ac8441351f38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c1ea4d4b03579953e9a66e331ae7514
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ade9bfa0f5e51eb2d9433d9336392162
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1406959642780906b253171a06b6b89b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_646acd82cfe6e936cb3079d5ea0a6c22 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate |
2011-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_141826e753cf3c6d2494c7bd9df6661d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d839a97e9e07fba5c3e1611b2aa2664
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2db8125265c43f2f77168e00d6b03748
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20cb1ae982ba83e7edcf595735897401 |
| publicationDate |
2015-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9074015-B2 |
| titleOfInvention |
Recombinantly expressed insulin polypeptides and uses thereof |
| abstract |
The present disclosure provides recombinantly expressed insulin polypeptides that comprise an N-linked glycan motif. The N-linked glycan motif is not present in wild-type insulins and enables the recombinant expression of glycosylated insulin polypeptides (e.g., in yeast cells). Based on results obtained with synthetic glycosylated insulin conjugates we predict that when these recombinant glycosylated insulin polypeptides are administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the glycosylated insulin polypeptide will be sensitive to serum concentrations of glucose (or an exogenous saccharide such as alpha-methyl mannose). Exemplary insulin polypeptides, polynucleotides encoding these insulin polypeptides, glycosylated insulin polypeptides, pharmaceutical formulations and sustained release formulations are provided in addition to methods of use and preparation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11352407-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10398781-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773151-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11261229-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016193351-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11267862-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11555058-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11213581-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015265717-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11359001-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11198719-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11186623-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11707517-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11192930-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11667689-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11673934-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9579391-B2 |
| priorityDate |
2010-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |