| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c1ea4d4b03579953e9a66e331ae7514
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e3bac293055c397a24c6bb515dec10a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a78efd004d2806590a8a887cf510e8f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4b85c452f0a5c5e04f810f463696594
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77c2f907d13534169a46ac8441351f38 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-42 |
| filingDate |
2011-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55758be04ff3f9f18777094dee29f342
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0877319263ac65e58ef3e0cbb6273527
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f91c7848a594ab83e8ea6495494f730
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68c0e2d177880e8b9494e9a65e1c98e1 |
| publicationDate |
2015-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9068013-B2 |
| titleOfInvention |
Recombinant lectins, binding-site modified lectins and uses thereof |
| abstract |
In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites and is covalently linked to a cysteine residue of the lectins; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11498951-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9579391-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11352406-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10398781-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015265717-A1 |
| priorityDate |
2010-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |