Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b5a573eab323e080f63d1fe8f495cd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e84cb6002fb18499ac6c633d535b9f72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_444ea225bf879f0387603a5f85e0a504 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a91b2c21a2da8f7711feca0c3d99123d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e8432ebff5a06ee8a6ffec8cc7611fbd |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 |
filingDate |
2010-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2014-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8044bcc5db9bb7c7f8b5a2b169341081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13f12bc02e95d659baa5a106b75f38e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b8d23be41991843196580278ce08acc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdf5e254fada06bc5e98e857c2fb796f |
publicationDate |
2014-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8921362-B2 |
titleOfInvention |
6,7-dialkoxy quinazoline derivatives and methods of treating drug resistant and other tumors |
abstract |
Compounds of formula (I) n nin which:n R 1 is: nn n n n n n n n n n R 2 is —CH 3 or —CH 2 CH 3 ; or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions including the compound of formula (I) and a pharmaceutically acceptable carrier. Processes for preparing the compound of formula (I). n n n Methods of inhibiting a receptor tyrosine kinase in a subject in need thereof. Methods of inhibiting the growth of a tumor cell in a subject in need thereof. Methods of treating pancreatic cancer in a subject in need of treatment for pancreatic cancer. Methods of treating HER2 positive breast cancer in a subject in need of treatment for HER2 positive breast cancer. Methods of treating drug resistant non-small cell lung cancer in a subject in need of treatment for drug resistant non-small cell lung cancer. Each of these methods can include administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9481655-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015141421-A1 |
priorityDate |
2008-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |