http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846373-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45175475a50c46fe71270701e3f621bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22af0c923d7537d54c62e7b66d4dceed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fee4331584b3730310853ebfa5f879b0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-04 |
| filingDate | 2012-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42a84f2d407038d8f6609575b6ee83cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce0460a777e7d7961ba3eaa938263f6f |
| publicationDate | 2014-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8846373-B2 |
| titleOfInvention | Methods of using a bacterial GlcNAc-6-P 2′- epimerase to promote sialylation of glycoconjugates |
| abstract | The present invention relates to new methods to promote sialylation of glycoconjugates, including recombinant glycoproteins, in glycoconjugate production systems. The invention relates to methods to promote efficient glycoconjugate sialylation in recombinant expression systems, by providing simpler and more economical ways to produce large intracellular pools of sialic acid precursors. The invention is directed to nucleic acids, vectors, and cells harboring vectors comprising nucleic acids encoding enzymes involved in the synthesis of sialic acid precursors, and cells harboring these nucleic acids in combination with nucleic acids encoding glycosyltransferases, including sialyltransferases, to facilitate the production of humanized recombinant glycoproteins in bacterial, fungal, plant, and animal cell expression systems. The engineered cells can be used to produce glycosylated proteins in virally-infected, transiently-transformed, or stably-transformed host cells, including lepidopteran insects and cultured cell lines derived from Spodoptera frugiperda, Trichoplusia ni , and Bombyx mori that can be infected by baculovirus expression vectors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9888674-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11666039-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10667500-B2 |
| priorityDate | 2011-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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