http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8697351-B2

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filingDate 2009-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74e9ed6bec99e735d1cdfef098ec1ca3
publicationDate 2014-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8697351-B2
titleOfInvention Method for measurement of physiologically active substance derived from organism and measurement apparatus
abstract Disclosed is a measurement method which can largely reduce the time required for the detection of a physiologically active substance derived from an organism (e.g., an endotoxin, β-D-glucan) or the determination of the concentration of the physiologically active substance by utilizing the reaction between the physiologically active substance and LAL. Also disclosed is a measurement apparatus utilizing the measurement method. An incident light from a light source is focused onto a sample and delivered to the sample to cause the bombardment with coagulin which is a final product of a protease cascade (i.e., a coagulin monomer) and an extremely fine aggregate which is produced by the aggregation of the coagulin monomers (i.e. a coagulin aggregate), thereby generating a scattered light. The scattered light is detected by a light-receiving element. The concentration of the endotoxin can be determined based on the initial rate of increase in the scattered light detected.
priorityDate 2008-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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