| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84eae33d82f6a8a8c86c1d865c6b762
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03582f1d29959412ac150c22017fc284
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_708c81ab8b0180dc83b0e1745551a975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71eed5467f00b9b39c598b59117c1f0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac6846efe78f8505e349b22f538937d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75909ceadd27ba93c1a16af6ad6bb9ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5c2d6a5a07914730d77e365aec0bf14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cfaa0174654827c94702aacb3b073bc2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afcfc7af43784847a2171ad49795c3c3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-03001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-14 |
| filingDate |
2011-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a3be4baec4cd10a585d01d9a8d5c8c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_461ca5a4e3657015d2d8e0c504825a0f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54dad2869f457468af672898ebcd701f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbe6780b64d2814c86f64d2720114c06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_589acb85836b9d3fa2ec3b70ab7609b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91c251297a55135b185be7a22f36081b |
| publicationDate |
2014-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8691208-B2 |
| titleOfInvention |
Compositions and methods for treating hypophosphatasia |
| abstract |
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11564978-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11654184-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11248021-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11352612-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11224637-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11400140-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10898549-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11065306-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116821-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10988744-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11338020-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11186832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10449236-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11229686-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10603361-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11224638-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11638699-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822596-B2 |
| priorityDate |
2005-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |