| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5c2d6a5a07914730d77e365aec0bf14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-03001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
| filingDate |
2009-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48d68e8587db72a8a758c650a259a8bc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_741543dd1aded914272cc2ad6a5ce5ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8057fa7cd8b4820a49706ac318109d59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1eda0bfa1e7d36b800837c2fd662c4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_059a255c473cc158f8e97f38168dda68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de72f20d8a117fd1a155032474e235ce |
| publicationDate |
2009-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009238814-A1 |
| titleOfInvention |
Compositions and methods for treating hypophosphatasia |
| abstract |
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11400140-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11564978-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11352612-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11229686-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10988744-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9988620-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010221234-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11224637-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7960529-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10603361-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2708068-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9266939-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11186832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10000532-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2015357551-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016090251-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10449236-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822596-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691208-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10052366-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11248021-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11065306-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10898549-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11224638-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010240125-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116821-B2 |
| priorityDate |
2005-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |