abstract |
The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device ( 10 ) can include an active agent reservoir ( 14 ) disposed in an annular housing ( 12 ), the annular housing ( 12 ) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device ( 10 ) can further include a semipermeable membrane ( 16 ) operatively coupled to the active agent reservoir ( 14 ), where the semipermeable membrane ( 16 ) is configured to allow diffusion of an active agent from the active agent reservoir ( 14 ). Additionally, a valve ( 18 ) can be operatively coupled to the active agent reservoir ( 14 ), where the valve ( 18 ) is configured to allow filling of the active agent reservoir ( 14 ) with an active agent. |