| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4283787e01be832f8fb90e8814b3e7de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_771da0d7bc57430b36c978566481b4e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47d25b1b2ec43e1afae9cc8248d29d51 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-90254 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-05 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-05 |
| filingDate |
2010-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9908d4f67566f9634d90c3d9a029b7cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d96db132a6dc0a9602cb883a3313f805
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_323b927ebc8d78bccf59dce87f17bdf4 |
| publicationDate |
2013-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8586292-B2 |
| titleOfInvention |
Methods for identifying compounds for treatment of thrombotic condition |
| abstract |
The present invention is directed to methods for sustaining eNOS activity to inhibit platelet aggregation, clot retraction, and enhance fibrinolysis. One embodiment of the invention provides methods of treating thrombosis by inhibiting the activity of the syk kinase. Another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by screening for compounds which sustain eNOS activity. Yet another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by identifying inhibitors of calpain and IIbIIIa by screening for compounds which act through calpain or IIbIIIa to sustain eNOS activity. Yet another embodiment provides for enhancing fibrinolysis, by inhibiting the activity of the syk kinase or calpain. |
| priorityDate |
2002-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |