| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2001-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e69183c906bd6939e5d71dcffd6b8a83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a747511f2d36e6b4b5c1d5c31d26ed5c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ba061287b1ed0a36395f2a1fe1f3e22 |
| publicationDate |
2002-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002128434-A1 |
| titleOfInvention |
Alpha-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
| abstract |
Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a first portion which targets a desired cysteine protease and positions the inhibitor near the thiolate anion portion of the active site of the protease, and a second portion which covalently bonds to the cysteine protease and irreversibly deactivates that protease by providing a carbonyl or carbonyl-equivalent which is attacked by the thiolate anion of the active site of the cysteine protease to sequentially cleave a β-dicarbonyl enol ether leaving group. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011124512-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006127385-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8586292-B2 |
| priorityDate |
1993-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |