| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b43982d3de7f615eac2708804cd2156c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e3cabe9863448209dcca52f959e58d3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3821d5cefb33539cfc31ca3d4c2ac3af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf1e9ecffa738ac6eab55155b2d2624f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-567 |
| filingDate |
2011-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3681420c6146d3c551ce4eea7add12f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c708ba96b4b4b8509fbd2972069d463d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_467256637bacd5e3fd086c19d994663a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7c9b3b788f72ae0e9f23cd3d7b85b94 |
| publicationDate |
2013-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8486647-B2 |
| titleOfInvention |
Neuropeptide release assay for sodium channels |
| abstract |
Methods and compositions for using genetically modified non-human animals are provided, wherein the genetic modification comprises a humanization of the one or more extracellular pore loops of a Na V 1.7 channel protein or a complete humanization of an endogenous Na V 1.7 gene. Methods for using isolated DRG cultures from genetically modified non-human animals are also provided, wherein the isolated DRG express a human or chimeric Na V 1.7 protein on the surface, in particular measuring primary nociceptive activation through the release of calcitonin gene-related peptide (CGRP) in isolated DRG in vitro, and wherein the isolated DRG cultures are capable of generating action potentials and communicating through an excitable signal via the expressed human or chimeric Na V 1.7 protein the cell surface. In vivo and in vitro methods for characterizing Na V 1.7-specific antagonists and evaluation of corresponding therapeutic potential for Na V 1.7-mediated disease are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017123804-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10711059-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8992927-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4257599-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8986694-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11753479-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9045545-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10618955-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11779604-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773175-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9062105-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9067998-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011307966-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871996-B2 |
| priorityDate |
2010-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |