| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc6b452b8abcf997a0f13383ec6d2360
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f13f13d64de7df82171c80fb9f3c8c76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36f12690a646f4748ac2bdf53149359a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d55491bc2d5b26c09849620ff1b26d7d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
| filingDate |
2009-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3414cb9f2b3206059a67019eb045d11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95cdefceefd5bb7859232c7024a2389f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6952e8bc207c1e7766c300e27a8e9b24 |
| publicationDate |
2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8431692-B2 |
| titleOfInvention |
Compositions and methods for treatment of ear disorders |
| abstract |
The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013210889-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738896-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9732343-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9101647-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9422560-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4035659-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11104887-B2 |
| priorityDate |
2008-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |