http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8431385-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fca7385dd05a207f69990d4a0d773254 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_350f6102c09f5e7553e36488239a0111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbba1211b8299648cd02a5441eaaee35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_031130a38c5d3181cdc7646ea0ae48e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca0ef733253dd9a7d5a8dbb668590384 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6c01708641d96915b4e1a1a32fa94f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_89b83c85f1fd4d60a8f8845fe6648ff7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2cb32d8fc6ca2d197e27c9a24580f0c3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F16-955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/H04L67-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0273 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N1-02 |
| filingDate | 2011-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f20d2bb91779695714ef280449890c88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a65add529ce35c5f19731708763fe435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fea610325c9ca8786e73d0f44e314902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_835c12c81f5f0b89d66d1b7ace954fde http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d42655716c28f098cac53c5f8450fc94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77025cc8c0f4230a0a3865b904b91417 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3adeb9bee0b588e8a46a39ae7178d1c7 |
| publicationDate | 2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8431385-B2 |
| titleOfInvention | Apparatus and method for maintaining and/or restoring viability of organs |
| abstract | An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. |
| priorityDate | 1998-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 452.