| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6d8e04ae4cd65626cf766efb75b9156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0249c8c96ed09a989cb0d43c51a3060d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73cc9f17b11bc7cfb48cc5d5208a416a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_390eedd0e5714afdd2aac3a21a2827fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7914af5095214b8c9d5169dcc470819
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fb4ca57dd9c91d3856ecaec3437ff31 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b557ab93a926b011f779988d9acb273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_799061524a048702e497a23d37ed71e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ff901a2c0188f0e8baa329cddd4bdec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e55f3353d27feb4ac62fa0b942bdde2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_666b9e6d6f108b08301603544c2f3d8a |
| publicationDate |
2013-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8426178-B2 |
| titleOfInvention |
Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| abstract |
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2- thienyl)-1-propanamine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10724008-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014150633-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11591625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019012095-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10093905-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286466-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018002676-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021061915-A3 |
| priorityDate |
2008-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |