abstract |
The present invention provides a catalyst system and a process for the preparation of a nonracemic chiral alcohol by hydrogenation of a ketone using the catalyst system, wherein the catalyst system comprises ruthenium, a nonracemic chiral diphosphine ligand, a bidentate amine ligand, and an organic base selected from alkylamidines, alkylguanidines, aminophosphazenes, and proazaphosphatranes. |